Stavroupoli – Xanthi (Greek: Σταυρούπολη) is a village and a former municipality in the Xanthi regional unit, East Macedonia and Thrace, Greece. Since the 2011 local government reform it is part of the municipality Xanthi, of which it is a municipal unit. The municipal unit has an area of 342.002 km2. Population 2,050 (2011). Stavroupoli and Nestos Valley (Greek: Κοιλάδα του Νέστου) including Nestos River Tempi (Greek: Τέμπη του Νέστου) is a popular tour region and vacation target in North Greece.
The municipal unit Stavroupoli is subdivided into the communities Dafnonas, Gerakas, Karyofyto, Komnina, Neochori, Paschalia and Stavroupoli. The community Stavroupoli consists of the settlements Stavroupoli, Lykodromi, Kallithea and Margariti.
During the Bulgarian occupation of the region in World War II from 1941 to 1944, the village was renamed Krastopole Bulgarian: Кръстополе and was infamous as the location of the Krastopole or Enikyoy concentration camp where Bulgarian Communist Party and other left-wing enemies of the ruling regime were interned.